ATTUD Journal Club Postings

Combination Varenicline and Nicotine Replacement Therapy

Recently three randomized, placebo-controlled trials have tested whether adding NRT to varenicline increases quit rates. The rationale for adding NRT to varencline typically involves hypothesizing a) varenicline does not bind to all nicotine receptors leaving some to be influenced by adding NRT, b) some smokers who do not respond fully to varenicline will be helped […]

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Varenicline vs. NRT: An Update

My ATTUD blog in April (“Is Varenicline More Effective than NRT?” – now on ATTUD website) concluded that varenicline was probably more effective than single NRT but whether it was better than dual NRT was unclear. Since then a new study and a new meta-analysis on this question have appeared that you may have heard […]

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Is Varenicline More Effective than NRT?

In several studies of varenicline vs. placebo, the magnitude of benefit from varenicline appeared to be more than that usually obtained with NRT. Only two randomized trials have directly compared varenicline with NRT. One trial was a large (n=746), well done study (Thorax 63:717) that found varenicline was more effective than standard dose NRT (26% […]

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